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Literature summary for 1.6.3.1 extracted from

  • Dakik, H.; El Dor, M.; Leclerc, J.; Kouzi, F.; Nehme, A.; Deynoux, M.; Debeissat, C.; Khamis, G.; Ducrocq, E.; Ibrik, A.; Stasia, M.J.; Raad, H.; Rezvani, H.R.; Gouilleux, F.; Zibara, K.; Herault, O.; Mazurier, F.
    Characterization of NADPH oxidase expression and activity in acute myeloid leukemia cell lines A correlation with the differentiation status (2021), Antioxidants (Basel), 10, 498 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens P04839 subunit cytochrome b-245 heavy chain
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Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
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 Homo sapiens
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THP-1 cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
cytochrome b-245 heavy chain
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function NOX2 is ubiquitously expressed in acute myeloid leukemia blasts, and particularly in cells from the myelomonocytic (M4) and monocytic (M5) stages. It is less expressed in leukemic stem cells and in relapsed acute myeloid leukemia. No endogenous NOX activity is detected in the absence of phorbol 12-myristate 13-acetate stimulation. Cytochrome b-245 heavy chain knockdown hampers induced NOX2 activity, but does not affect the proliferation and differentiation of THP-1 and HL-60 cells Homo sapiens